Pre-congress course and workshop on updated cytogenetic assays applicable for Genetic Toxicology

23 – 24 March, 2019 | Leiden University Medical Centre


Harmonizing Genetic Toxicology Testing: Application of Short-term Cytogenetic Assays


It has become evident that there is a direct link between higher incidence of chromosomal abnormalities such as chromosomal aberrations and micronuclei in humans with cancer.

Various cytogenetic assays have been standardized and validated in different systems in vitro and in vivo, and were successfully applied to elucidate the genotoxic and mutagenic potential of physical (such as radiation of different qualities), and chemicals (such as environmental pollutants, cytostatic drugs and human dietary components).

This two days course offers a wonderful opportunity to become familiar with the general scope and aims of important field of genetic toxicology for human risk assessment, and will offer a technical hands-on portion which will acquaint participants with two established and updated cytogenetic assays (Chromosome aberrations in metaphase and interphase cells and micronuclei in binucleated cells). These assays are applicable for both basic as well as applied scientific research programs.

These assays are suitable for elucidating the genotoxic potential of different classes of human cytotoxicants, mutagens and/or carcinogens at biologically relevant doses to human exposure. Furthermore, can detect and discriminate between carcinogens and non-carcinogens.

Topics of Genetic Toxicology Course:

  1. Theoretical

Participants will learn how to develop and validate biological assays to detect the genotoxic potential of physical and chemical agents. The advantages and pitfalls of each assay will be specified. Furthermore, the optimal and most reliable experimental conditions to assess genotoxic, co- and anti-genotoxic potential of human dietary components will be presented.

  1. Practical

Course attendees will participate in hands-on laboratory portion individually and will learn culturing, how to perform chromosome aberration and micronucleus assays (including all technical terms and conditions), scoring criteria and slide analysis.

Due to space requirements participants are limited to 20, so register today*

Course organizer:

This course is being organized and taught by Dr. Firouz Darroudi (Chairman of the GHI 2019 scientific committee, and co-chair of GHI 2019 organizing committee)

*For registering and / or receiving more information please contact secretary of GHI-2019 congress.
Dead-line for registering is 28 December 2018, and applicants will receive a note of acceptance on 4 January 2019.